diff --git a/environment.yml b/environment.yml
index 96f2c8d2086c7..4622aac1dc6f8 100644
--- a/environment.yml
+++ b/environment.yml
@@ -21,7 +21,7 @@ dependencies:
   - flake8-comprehensions>=3.1.0  # used by flake8, linting of unnecessary comprehensions
   - flake8-rst>=0.6.0,<=0.7.0  # linting of code blocks in rst files
   - isort>=5.2.1  # check that imports are in the right order
-  - mypy=0.730
+  - mypy=0.782
   - pycodestyle  # used by flake8
 
   # documentation
diff --git a/pandas/_config/config.py b/pandas/_config/config.py
index fb41b37980b2e..0b802f2cc9e69 100644
--- a/pandas/_config/config.py
+++ b/pandas/_config/config.py
@@ -460,9 +460,7 @@ def register_option(
     path = key.split(".")
 
     for k in path:
-        # NOTE: tokenize.Name is not a public constant
-        # error: Module has no attribute "Name"  [attr-defined]
-        if not re.match("^" + tokenize.Name + "$", k):  # type: ignore[attr-defined]
+        if not re.match("^" + tokenize.Name + "$", k):
             raise ValueError(f"{k} is not a valid identifier")
         if keyword.iskeyword(k):
             raise ValueError(f"{k} is a python keyword")
diff --git a/pandas/core/common.py b/pandas/core/common.py
index e7260a9923ee0..6fd4700ab7f3f 100644
--- a/pandas/core/common.py
+++ b/pandas/core/common.py
@@ -9,7 +9,7 @@
 from datetime import datetime, timedelta
 from functools import partial
 import inspect
-from typing import Any, Collection, Iterable, Iterator, List, Union
+from typing import Any, Collection, Iterable, Iterator, List, Union, cast
 import warnings
 
 import numpy as np
@@ -277,6 +277,11 @@ def maybe_iterable_to_list(obj: Union[Iterable[T], T]) -> Union[Collection[T], T
     """
     if isinstance(obj, abc.Iterable) and not isinstance(obj, abc.Sized):
         return list(obj)
+    # error: Incompatible return value type (got
+    # "Union[pandas.core.common.<subclass of "Iterable" and "Sized">,
+    # pandas.core.common.<subclass of "Iterable" and "Sized">1, T]", expected
+    # "Union[Collection[T], T]")  [return-value]
+    obj = cast(Collection, obj)
     return obj
 
 
diff --git a/pandas/core/computation/expr.py b/pandas/core/computation/expr.py
index 125ecb0d88036..df71b4fe415f8 100644
--- a/pandas/core/computation/expr.py
+++ b/pandas/core/computation/expr.py
@@ -364,7 +364,7 @@ class BaseExprVisitor(ast.NodeVisitor):
 
     unary_ops = _unary_ops_syms
     unary_op_nodes = "UAdd", "USub", "Invert", "Not"
-    unary_op_nodes_map = dict(zip(unary_ops, unary_op_nodes))
+    unary_op_nodes_map = {k: v for k, v in zip(unary_ops, unary_op_nodes)}
 
     rewrite_map = {
         ast.Eq: ast.In,
diff --git a/pandas/core/indexes/frozen.py b/pandas/core/indexes/frozen.py
index 909643d50e9d7..8c4437f2cdeb9 100644
--- a/pandas/core/indexes/frozen.py
+++ b/pandas/core/indexes/frozen.py
@@ -103,5 +103,7 @@ def __str__(self) -> str:
     def __repr__(self) -> str:
         return f"{type(self).__name__}({str(self)})"
 
-    __setitem__ = __setslice__ = __delitem__ = __delslice__ = _disabled
-    pop = append = extend = remove = sort = insert = _disabled
+    __setitem__ = __setslice__ = _disabled  # type: ignore[assignment]
+    __delitem__ = __delslice__ = _disabled  # type: ignore[assignment]
+    pop = append = extend = _disabled  # type: ignore[assignment]
+    remove = sort = insert = _disabled  # type: ignore[assignment]
diff --git a/pandas/core/resample.py b/pandas/core/resample.py
index fc54128ae5aa6..7b5154756e613 100644
--- a/pandas/core/resample.py
+++ b/pandas/core/resample.py
@@ -966,8 +966,7 @@ def __init__(self, obj, *args, **kwargs):
         for attr in self._attributes:
             setattr(self, attr, kwargs.get(attr, getattr(parent, attr)))
 
-        # error: Too many arguments for "__init__" of "object"
-        super().__init__(None)  # type: ignore[call-arg]
+        super().__init__(None)
         self._groupby = groupby
         self._groupby.mutated = True
         self._groupby.grouper.mutated = True
diff --git a/requirements-dev.txt b/requirements-dev.txt
index 1fca25c9fecd9..cc3775de3a4ba 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -12,7 +12,7 @@ flake8<3.8.0
 flake8-comprehensions>=3.1.0
 flake8-rst>=0.6.0,<=0.7.0
 isort>=5.2.1
-mypy==0.730
+mypy==0.782
 pycodestyle
 gitpython
 gitdb
diff --git a/setup.cfg b/setup.cfg
index c10624d60aaff..2114909256a7a 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -127,10 +127,7 @@ show_error_codes = True
 [mypy-pandas.tests.*]
 check_untyped_defs=False
 
-[mypy-pandas.conftest]
-ignore_errors=True
-
-[mypy-pandas.tests.tools.test_to_datetime]
+[mypy-pandas.conftest,pandas.tests.window.conftest]
 ignore_errors=True
 
 [mypy-pandas._testing]
@@ -139,7 +136,22 @@ check_untyped_defs=False
 [mypy-pandas._version]
 check_untyped_defs=False
 
-[mypy-pandas.core.arrays.interval]
+[mypy-pandas.compat.pickle_compat]
+check_untyped_defs=False
+
+[mypy-pandas.core.apply]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.base]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.datetimelike]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.sparse.array]
+check_untyped_defs=False
+
+[mypy-pandas.core.arrays.string_]
 check_untyped_defs=False
 
 [mypy-pandas.core.base]
@@ -151,6 +163,9 @@ check_untyped_defs=False
 [mypy-pandas.core.computation.expressions]
 check_untyped_defs=False
 
+[mypy-pandas.core.computation.ops]
+check_untyped_defs=False
+
 [mypy-pandas.core.computation.pytables]
 check_untyped_defs=False
 
@@ -163,6 +178,9 @@ check_untyped_defs=False
 [mypy-pandas.core.generic]
 check_untyped_defs=False
 
+[mypy-pandas.core.groupby.base]
+check_untyped_defs=False
+
 [mypy-pandas.core.groupby.generic]
 check_untyped_defs=False
 
@@ -172,15 +190,33 @@ check_untyped_defs=False
 [mypy-pandas.core.groupby.ops]
 check_untyped_defs=False
 
+[mypy-pandas.core.indexes.base]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.category]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.datetimelike]
+check_untyped_defs=False
+
 [mypy-pandas.core.indexes.datetimes]
 check_untyped_defs=False
 
+[mypy-pandas.core.indexes.extension]
+check_untyped_defs=False
+
 [mypy-pandas.core.indexes.interval]
 check_untyped_defs=False
 
 [mypy-pandas.core.indexes.multi]
 check_untyped_defs=False
 
+[mypy-pandas.core.indexes.period]
+check_untyped_defs=False
+
+[mypy-pandas.core.indexes.range]
+check_untyped_defs=False
+
 [mypy-pandas.core.internals.blocks]
 check_untyped_defs=False
 
@@ -190,15 +226,27 @@ check_untyped_defs=False
 [mypy-pandas.core.internals.managers]
 check_untyped_defs=False
 
+[mypy-pandas.core.internals.ops]
+check_untyped_defs=False
+
 [mypy-pandas.core.missing]
 check_untyped_defs=False
 
 [mypy-pandas.core.ops.docstrings]
 check_untyped_defs=False
 
+[mypy-pandas.core.resample]
+check_untyped_defs=False
+
+[mypy-pandas.core.reshape.concat]
+check_untyped_defs=False
+
 [mypy-pandas.core.reshape.merge]
 check_untyped_defs=False
 
+[mypy-pandas.core.series]
+check_untyped_defs=False
+
 [mypy-pandas.core.strings]
 check_untyped_defs=False
 
@@ -214,6 +262,9 @@ check_untyped_defs=False
 [mypy-pandas.io.clipboard]
 check_untyped_defs=False
 
+[mypy-pandas.io.common]
+check_untyped_defs=False
+
 [mypy-pandas.io.excel._base]
 check_untyped_defs=False
 
@@ -232,6 +283,9 @@ check_untyped_defs=False
 [mypy-pandas.io.formats.css]
 check_untyped_defs=False
 
+[mypy-pandas.io.formats.csvs]
+check_untyped_defs=False
+
 [mypy-pandas.io.formats.excel]
 check_untyped_defs=False
 
@@ -270,3 +324,10 @@ check_untyped_defs=False
 
 [mypy-pandas.plotting._matplotlib.misc]
 check_untyped_defs=False
+
+[mypy-pandas.plotting._misc]
+check_untyped_defs=False
+
+[mypy-pandas.util._decorators]
+check_untyped_defs=False
+