diff --git a/.circleci/config.yml b/.circleci/config.yml
index 828fcf44f6..a5d59eb75b 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -340,8 +340,8 @@ jobs:
           name: Check pypi preconditions
           command: |
             pip install --upgrade pip twine future wheel readme_renderer setuptools
-            python setup.py check -r -s
             python setup.py sdist bdist_wheel
+            twine check dist/*
       - run:
           name: Validate Python 2 installation
           command: |
@@ -368,6 +368,14 @@ jobs:
             pip install dist/nipype-*-py2.py3-none-any.whl
             # Numpy should be upgraded to >= 1.15.3
             test "$(pip show numpy | grep Version)" \> "Version: 1.15.2"
+      - run:
+          name: Check python_requires prevents installation on Python 3.3
+          command: |
+            pyenv install 3.3.7
+            pyenv local 3.3.7
+            FAIL=false
+            pip install dist/nipype-*-py2.py3-none-any.whl || FAIL=true
+            $FAIL
       - store_artifacts:
           path: /home/circleci/nipype/dist
 
diff --git a/nipype/info.py b/nipype/info.py
index f03e625dda..827bc93a12 100644
--- a/nipype/info.py
+++ b/nipype/info.py
@@ -61,6 +61,7 @@ def get_nipype_gitversion():
     'Programming Language :: Python :: 3.7',
     'Topic :: Scientific/Engineering'
 ]
+PYTHON_REQUIRES = ">= 2.7, != 3.0.*, != 3.1.*, != 3.2.*, != 3.3.*"
 
 description = 'Neuroimaging in Python: Pipelines and Interfaces'
 
diff --git a/setup.py b/setup.py
index 37677afd35..72ba59d904 100755
--- a/setup.py
+++ b/setup.py
@@ -139,6 +139,7 @@ def main():
         author_email=ldict['AUTHOR_EMAIL'],
         platforms=ldict['PLATFORMS'],
         version=ldict['VERSION'],
+        python_requires=ldict['PYTHON_REQUIRES'],
         install_requires=ldict['REQUIRES'],
         setup_requires=SETUP_REQUIRES,
         provides=ldict['PROVIDES'],